Health & Wellness Supplements

57 // CoQ10: A Comprehensive Guide to This Essential Nutrient

December 15, 2025

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I'm Lisa, functional medicine dietitian, certified nutritionist, and gut health expert helping you find health and wellness you deserve!

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Every now and then, a nutrient steps into the wellness spotlight and quietly steals the show. Coenzyme Q10—better known as CoQ10—is one of those under-the-radar heroes. It’s not trendy or flashy. You won’t see it dancing around TikTok. But if you ask the research community, your mitochondria, or literally any cell in your body, CoQ10 is the VIP guest of the health and longevity world.

And yet… most people know next to nothing about it.

So let’s break down the science in a way you can actually use. Because CoQ10 isn’t just “nice to have.” It’s essential. And understanding how it supports your energy, heart health, hormones, skin, metabolism, and aging process is one of the smartest health moves you’ll ever make.

Let’s dig in.

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What Exactly Is CoQ10? Your Cellular Spark Plug

CoQ10 is a naturally occurring antioxidant your body makes on its own. It lives inside every single cell and plays the starring role in one major function:

🔥 Energy production.
This enzyme is required to convert the food you eat into ATP—the energy currency that powers everything from blinking to weight lifting to thinking clearly during a Zoom call.

It’s like the spark plug in your cellular engine. No spark = no energy.

But here’s where things take a turn:

  • CoQ10 levels peak in your teens and 20s
  • They begin declining around age 30
  • By age 40, your levels drop even more
  • By age 60, they’re dramatically reduced

And that decline affects… well, everything.

Because your high-energy organs—heart, brain, kidneys, liver—are the most CoQ10-hungry. When levels dip, you feel it in stress capacity, stamina, mental clarity, and aging.

Add to that modern-life free radicals (hello unfiltered water, chemicals, air pollution, ultra-processed foods), and your CoQ10 gets used up even faster trying to protect you.

Which brings us to one of its biggest superpowers…


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Your Built-In Antioxidant Bodyguard

This enzyme powerhouse is one of the major defenders in your antioxidant lineup. Not just because it neutralizes free radicals, but because it also rescues other antioxidants—like vitamins C and E—when they’re used up.

Think of CoQ10 as the friend who helps you clean the kitchen and reloads the dishwasher.

Antioxidant support is crucial because free radicals are constantly formed from:

  • metabolic processes
  • stress
  • medications
  • pollution
  • poor sleep
  • toxins
  • blood sugar swings

Left unchecked, free radicals contribute to:

  • premature aging
  • wrinkles and collagen loss
  • inflammation
  • chronic disease
  • brain fog
  • low energy
  • cardiovascular damage

CoQ10 helps stop the chain reaction of damage before it accelerates.

And that’s just the beginning.


The Science-Backed Benefits (a.k.a. Why You Should Care)

Let’s break this down in a digestible, “why this matters to my life right now” kind of way.


1. More Natural Energy + Better Metabolism

Since CoQ10 is required for ATP production, low levels often show up as:

  • fatigue
  • sluggish metabolism
  • exercise intolerance
  • mental fatigue
  • “running on fumes”

When people begin supplementing with this incredible enzyme, the most common feedback is:

“I didn’t realize how tired I was until I started feeling better.”

Because when your mitochondria have what they need, your entire system runs more smoothly.

This alone would be reason enough to care about CoQ10.

But we’re not done.


2. A Major Player in Heart & Muscle Health

Your heart uses a lot of energy to function properly. That makes CoQ10 a key nutrient for cardiovascular function.

Research shows CoQ10 can help:

  • support cognitive health
  • support healthy blood pressure
  • reduce oxidative stress in the heart
  • improve circulation
  • reduce muscle pain and weakness—especially in people taking statins

And this is huge:
Statin medications deplete your body’s CoQ10 levels by 40% – 54%.
That’s one reason many people on statins experience muscle aches and fatigue.

Supplementing CoQ10 often helps reduce those side effects and may even improve overall tolerance of the medication.


3. A Potent Anti-Aging Ally for Skin + Cells

CoQ10 is deeply involved in slowing cellular aging.

It has been shown to:

  • reduce wrinkles
  • protect skin from UV damage
  • improve skin elasticity
  • support collagen preservation
  • minimize oxidative stress in skin cells

Topical CoQ10 helps—but internal CoQ10 does far more because it protects your system from the inside out.


4. A Fertility Booster for Men and Women

Fertility declines with age partly because of mitochondrial damage and oxidative stress. CoQ10 helps stabilize both.

For women:
CoQ10 supports mitochondrial function in the ovaries, improving egg quality—especially after age 35.

For men:
It enhances sperm count, motility, and morphology.

If you or someone you know is exploring fertility support, CoQ10 is often one of the first recommendations in functional medicine for a reason.


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5. Cognitive + Neurological Support

The brain is an energy-demanding organ and extremely sensitive to oxidative stress.

CoQ10 supports:

  • mental clarity
  • memory
  • focus
  • healthy mitochondrial function in the brain

It’s also being studied for conditions like Parkinson’s and Alzheimer’s because of its neuroprotective effect.

While it’s not a cure, it’s a meaningful tool for supporting long-term cognitive health.


How to Get CoQ10 from Food (and Why It’s Not Always Enough)

You can get small amounts of CoQ10 through foods like:

  • organ meats (liver, heart)
  • fatty fish (mackerel, trout, sardines)
  • nuts and seeds
  • broccoli
  • cauliflower
  • spinach
  • strawberries

The challenge?

Food sources don’t provide enough to compensate for age-related decline, medication depletion, or increased oxidative stress from modern living.

For women in their 40s and 50s—navigating hormone shifts, changes in energy, and more inflammation—dietary sources alone often aren’t enough.

Which brings us to supplementation.


CoQ10 Supplements: What to Look For (and What Actually Works)

There are two primary forms of CoQ10:

✔️ Ubiquinone (the oxidized form)

Cheaper, widely available, but must be converted by the body.

✔️ Ubiquinol (the reduced, active form)

More bioavailable, especially helpful for adults over 40.

Your body can convert between the two, but conversion slows with age. That’s why many practitioners recommend ubiquinol for optimal absorption.

Most people benefit from 100–200 mg/day, though some protocols use more under medical supervision.

Tips for choosing a supplement:

  • Look for reputable brands with third-party testing
  • Avoid fillers, dyes, or additives
  • Choose softgels with healthy fats (better absorption)
  • If taking statins, time your CoQ10 at a different part of the day

Remember: your body doesn’t store CoQ10 well, so daily consistency is key.


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Is CoQ10 Safe? (Spoiler: Usually Yes, With a Few Notes)

For most adults, CoQ10 is extremely safe.
Side effects—when they happen—are mild:

  • digestive upset
  • headache
  • nausea

However, you should talk to your practitioner if you’re on:

  • blood thinners
  • beta blockers
  • certain antidepressants
  • fertility medications
  • immunosuppressants
  • statins

And skip CoQ10 for kids unless a provider specifically recommends it.


Who Benefits Most from CoQ10?

While almost everyone can benefit from better antioxidant support and energy production, certain groups tend to see the biggest improvements:

  • adults 40+
  • people under chronic stress
  • those with inflammatory conditions
  • people on statins
  • those trying to conceive
  • athletes or active individuals
  • anyone experiencing chronic fatigue
  • people with blood sugar instability
  • those exposed to environmental toxins

How CoQ10 Fits Into a Whole-Body Wellness Strategy

CoQ10 isn’t a magic pill, but it’s a powerful piece of the puzzle.

Pairing it with foundational daily habits amplifies its benefits:

  • eating balanced, nutrient-rich meals
  • prioritizing sleep
  • dialing down inflammation
  • supporting gut health
  • managing stress
  • moving your body daily
  • using antioxidants strategically

It’s especially helpful during midlife transitions, when energy dips, hormones shift, and oxidative stress rises.

Your cells need more support, not less, during these seasons.


The Bottom Line: CoQ10 Is One of the Most Underrated Tools for Energy, Longevity & Metabolic Health

If you want:

  • better energy
  • clearer thinking
  • steadier metabolism
  • improved exercise recovery
  • hormonal support
  • heart health
  • anti-aging benefits
  • better mitochondrial function

…CoQ10 may belong in your wellness toolkit.

It’s one of those quiet, powerful nutrients that works behind the scenes to help your body age gracefully, function efficiently, and feel like its most vibrant, capable self.

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